NF-κB as a therapeutic drug target

Nuclear factor kappaB (NF-kappaB) pathway as a therapeutic target in rheumatoid arthritis.

Rheumatoid arthritis (RA) is a chronic inflammatory disease characterized by persistent joint swelling and progressive destruction of cartilage and bone. Current RA treatments are largely empirical in origin and their precise mechanism of action is uncertain. Increasing evidence shows that chronic inflammatory diseases such as RA are caused by prolonged production of proinflammatory cytokines i...

The nuclear factor-kappaB (NF-kappaB): from a versatile transcription factor to a ubiquitous therapeutic target.

The nuclear factor-kappaB (NF-kappaB) transcription factors regulate a plethora of cellular pathways and processes including the immune response, inflammation, proliferation, apoptosis and calcium homeostasis. In addition to the complexity of its physiological roles, the composition and function of this family of proteins is very complicated. While the basic understanding of NF-kappaB signallin...

The nuclear factor-kappaB (NF-κB): from a versatile transcription factor to a ubiquitous therapeutic target

The nuclear factor-κappaB (NF-κB) transcription factors regulate a plethora of cellular pathways and processes including the immune response, inflammation, proliferation, apoptosis and calcium homeostasis. In addition to the complexity of its physiological roles, the composition and function of this family of proteins is very complicated. While the basic understanding of NF-κB signalling is ext...

Relief from a heavy heart: redox-sensitive NF-kappaB as a therapeutic target in managing cardiac hypertrophy.

CARDIAC HYPERTROPHY is both an adaptive response to chronic pressure overload and a key risk factor in patients with hypertension (6). On one hand, cardiac hypertrophy may normalize wall tension, whereas on the other it may progress to a decompensated state causing overt heart failure, a common end stage of numerous cardiac disorders. Mechanisms of progression to heart failure include renal sod...

NF-κB as a Therapeutic Target in Multiple Myeloma